Here, we have found that a central component of Wnt signaling and a transcriptional regulator in EMT, β-catenin 2, 40, 41, drives the expressions of TNFAIP6, LAMC2, CD44, and JUN during active PLK1-driven or TGF-β-induced EMT, functioning as a transcriptional factor in NSCLC. The gene discussed is TNFAIP6; the disease is non-small cell lung carcinoma.