Regardless of the alanine substitution at GSK3β and CK1α (β-cateninmtGSK3β) phosphorylation sites, cells expressing phosphomimetic β-catenin at Ser311 upregulated the levels of CD44, p-PLK1, and mesenchymal factors and promoted cell motility and invasiveness of NSCLC. Here, CSNK1A1 is linked to non-small cell lung carcinoma.