Catalytically active PLK1 promotes metastasis in non-small cell lung cancer (NSCLC) through the amplification of TGF-β signaling 20 and shows a high frequency of extracellular matrix (ECM)-adhesion, immune system, and TGF-β signaling in the KEGG pathway analysis of transcriptome profiles and highly expressed ECM adhesion-related genes, including TNFAIP6, LAMC2, and LCE3D, which are the top three genes in microarray analysis 19. The gene discussed is LCE3D; the disease is non-small cell lung carcinoma.