The AUROC of GPR for the prediction of significant and extensive liver fibrosis was better than that of APRI and FIB-4, but there were no statistically significant differences observed between GPR and APRI (P = 0.1241), and GPR and FIB-4 (P = 0.3761) (Figure 1 and Figure 2, Table 4 and Table 5). This evidence concerns the gene ALDH18A1 and Hepatic fibrosis.