CHB: chronic hepatitis B virus, HBeAg: hepatitis B envelope antigen, GPR: gamma-glutamyl transpeptidase-to-platelet ratio, APRI: aspartate aminotransferase-to-platelet ratio index, FIB-4: fibrosis-4 index, TE: transient elastography, AUROC: area under the receiver operating characteristic curves, NAFLD: nonalcoholic fatty liver disease. The gene discussed is GGTLC1; the disease is metabolic dysfunction-associated steatotic liver disease.