SOD1 and amyotrophic lateral sclerosis: 75–79 Altered maturation and modifications in SOD1 have also been demonstrated in such patients.80 It is currently not known whether these aberrations in SOD1 have any pathogenic role.81 Hypothetically, the ISODDES findings presented here combined with almost 30 years of research into how mutations in a ubiquitously expressed protein cause adult-onset ALS are best explained by SOD1 having one or more yet-to-be-defined specific roles in motor areas.