We induced hemorrhagic stroke by severely increasing blood pressure through combined angiotensin II (Ang II) administration, a high-salt (HS) diet ad libitum, and drinking water supplemented with the nitric oxide synthase (NOS) inhibitor Nitro-L-arginine methyl ester hydrochloride (L-NAME) in control (Trpa1fl/fl) and endothelial cell-specific TRPA1 knockout (Trpa1-ecKO). This evidence concerns the gene TRPA1 and hemorrhagic stroke.