In addition, expression of NOX1, NOX2, and NOX4 significantly increases in brain tissue and the cerebral vasculature after stroke, and these enzymes are a substantial source of pathological ROS following intracerebral hemorrhage (Wakisaka et al., 2008; Wakisaka et al., 2010a; Zhang et al., 2016). The gene discussed is NOX4; the disease is stroke disorder.