Some scholars found that the expressions of Notch1 and Jagged1 were significantly upregulated in the kidney tissues of IgA nephropathy, and Notch1, HEY1, and HES1 were significantly reduced after administration of the Notch1 pathway inhibitor DAPT, thereby alleviating RIF [49]. Here, HEY1 is linked to IgA glomerulonephritis.