In fact, TAMs in SCC, due to weaker classical macrophage activation and higher production of tumorigenic growth factors, are unable to prevent tumor genesis and in fact they can even facilitate tumor growth; however, they contribute to tumor invasion and metastasis through production of high levels of MMPs, more dominant M2 activation and lymphangiogenic mediator (VEGF-C) expression (27). The gene discussed is VEGFC; the disease is neoplasm.