VEGFA and neoplasm: To illustrate, VEGF is one of the most important angiogenic factors that promote the development and progression of tumors by increasing microvascular permeability and directly stimulating endothelial cell growth and angiogenesis; a recent clinical study (84) on 173 patients with EC found that the serum levels of VEGF and components of the plasminogen activator system at primary diagnosis correlated significantly with the prognosis and clinicopathological risk factors, including disease stage, tumor histology, tumor grade, myometrial invasion, and lymph node metastases.