GCNT1, a putatively causal gene for IgE concentration as implicated in our MR analysis of gene expression in relation to IgE levels (beta=1.503, p=0.01; Table 5), is also one of the top results in the MR analysis of expression in relation to asthma and allergic diseases (beta=58.12, p<1×10-400 and beta=58.88, p<1×10-400, respectively; Table 6 and Supplementary Table 7). This evidence concerns the gene IGHE and allergic disease.