RIG-I is a PRR that recognizes different viral infections, such as the ones we have used in this work [e.g. SARS-CoV-2 (47, 48, 66), IAV (50, 51), and SeV (51)], as well as transfected poly(I:C) (52), being its activation tightly regulated [reviewed in (13)]. Here, RIGI is linked to viral infectious disease.