To confirm that IFI6 is an ISG in our cell culture systems, epithelial human lung adenocarcinoma-derived A549 cells were treated with poly(I:C), an analog of dsRNA, or with IFNα, for 16 h, and the levels of IFI6 were measured by RT-qPCR, and compared to the levels in mock-treated cells. Here, IFNA1 is linked to lung adenocarcinoma.