IBD-relevant proinflammatory cytokines TNF/IL17 increased the expression and release of chemokines which attract neutrophil granulocytes and monocytes at both 20% and 2% oxygen (75, 76), but with a reduction in TNF and TNF/IL17 induced responses in 2% oxygen, indicating anti-inflammatory traits of physioxia. The gene discussed is IL17A; the disease is inflammatory bowel disease.