In multivariate analysis, early tumor response was independently correlated with OS (HR= 0.404, 95% CI: 0.171–0.954; p=0.039) and jointly with the following conditions: baseline AFP>400 ng/mL (p=0.020), portal vein tumor thrombosis (PVTT) (p=0.011), and extrahepatic metastasis (p=0.001)(Table 5, Multivariate model 1). This evidence concerns the gene AFP and neoplasm.