These false positive results may derive from somatic non-tumor changes in genes derived from clonal hematopoiesis indeterminate potential (CHIP), including ASXL1, ATM, CBL, CHEK2, DNMT3A, JAK2, KMT2D, MLL2, MPL, MYD88, SF3B1, TET2, TP53 and U2AF1 (109–113). The gene discussed is CHEK2; the disease is neoplasm.