Figure 1A demonstrated that the m6A level upregulated in OSCC and OED tissues compared with normal control. It was found that m6A methylation regulators were expressed to different degrees in various cancer types, and the expressions of METTL3, WTAP, ZC3H13, KIAA1429, YTHDC, YTHDF2, YTHDF3, HNRNPA2B, HNRNPC, LRPPRC, IGF2BP2 and IGF2BP3 in HNSCC were higher, among which KIAA1429, YTHDF3, IGF2BP2, and IGF2BP3 had significant differences in the corresponding studies (Supplementary Material). The gene discussed is LRPPRC; the disease is head and neck squamous cell carcinoma.