To analyze the expression of 23 methylation regulators in the cancer genome atlas (TCGA) in HNSCC and normal tissues, we searched the GEPIA database and found that only the m6A methylation regulators IGF2BP2 and IGF2BP3 had significant differences in expression in HNSCC than in normal tissues (P<0.05) (Figure 1C), which was consistent with the results from the Oncomine database. The gene discussed is IGF2BP3; the disease is cancer.