Among them, the HER2-HER3 heterodimer is the most active HER signaling dimer and plays a crucial role in HER2-driven tumor oncogenic transformation, HER-2 activates downstream pathways through heterodimerization and tyrosine kinase autophosphorylation mediated signal transduction, major signaling pathways include Ras/MAPK and PI3K/Akt (14). Here, ERBB2 is linked to neoplasm.