CNTFR and lung adenocarcinoma: Kim et al. [48] found the functional significance of the cardiotrophin-like cytokine factor 1-ciliary neurotrophic factor receptor (CLCF1-CNTFR) signalling axis in lung adenocarcinoma (LUAD) and engineered a high-affinity soluble receptor (eCNTFR-Fc) that sequesters CLCF1, thereby inhibiting its oncogenic effects.