ANXA1 and metabolic dysfunction-associated steatohepatitis: The endogenous ligand for FPR2, annexin A1, has also shown beneficial effects in reducing fibrosis in a mouse model of non-alcoholic steatohepatitis (NASH) (143), while the Annexin A1 derived peptide Ac2-26 reduced collagen deposition in a model of silicosis (144).