In the superficial dorsal horn of the T2 spinal cord, myocardial ischemia-induced neural cell activation, represented by percent of cFos+/NeuN+ double-labeled cells (41 ± 13%), was significantly reduced by DRGS (7.8 ± 3.4%, p = 0.0476, Figure 4A, representative expressions shown in Figure 4B). Here, FOS is linked to myocardial ischemia.