From this, we noticed that hnRNPA3 is present in the cell nucleus in healthy tissues, whereas in tissues of patients with C9orf72 FTLD/ALS, nuclear staining was variably lost, and hnRNPA3-positive inclusion pathology was observed in the hippocampal dentate gyrus (37). This evidence concerns the gene HNRNPA3 and amyotrophic lateral sclerosis.