Hypermethylation was deemed as β value cut-off (β value: 0.7–0.5) including CD4, PTPRC, ITGB2, TYROBP, BIRC5, and ITGAM, and all exhibited higher methylation levels in ccRCC tissues compared with paired tumor-free kidney tissues (Figure 4). The gene discussed is CD4; the disease is nonpapillary renal cell carcinoma.