The progression of CRA to CRC may be influenced by three key DEMs (hsa-miR-34c-5p, hsa-miR-320a, and hsa-miR-338-3p) and six key DEGs (BCL2, PPM1L, ARHGAP44, PRKACB, TPD52L2, and WNK4). Here, PPM1L is linked to colorectal carcinoma.