At the early stage of carcinogenesis, p53 functions as a cell non-autonomous tumor suppressor in the fibroblasts, in part by preventing the production and secretion of several molecules that might promote tumor growth (Kiaris et al., 2005; Moskovits et al., 2006; Addadi et al., 2010; Otomo et al., 2014). Here, TP53 is linked to neoplasm.