With the key monocyte chemotactic cytokines MCP-1 and SDF-1, the CAFs from invasive human breast cancer were able to transform monocytes into M2-type pro-tumoral macrophages, changing the myeloid lineage structurally as well as functionally (Gok Yavuz et al., 2019). The gene discussed is CXCL12; the disease is breast cancer.