FN1 and neoplasm: In contrast to the physiological context, fibronectin fibers are not let relaxed to resume quiescence; instead, the fibronectin zones are altered as a preventive measure against relaxation, which, in turn, leads to continuous ECM remodeling in the tumor context (Cox and Erler, 2011; Pickup et al., 2014; Leight et al., 2017; Barbazán and Matic Vignjevic, 2019).