A few other molecules causing EMT and stemness are Serglycin (SRGN), Annexin A1 (AnxA1), and Prostaglandin E2 (PGE2), all of which are derived from activated CAFs and act through paracrine signaling on the non-small cell lung cancer (NSCLC) cells, prostate cancer cells, and intestinal cancer cells respectively (Geary et al., 2014; Guo et al., 2017; Roulis et al., 2020). This evidence concerns the gene SRGN and Familial prostate cancer.