POSTN and head and neck squamous cell carcinoma: TGFβ3 produced from head and neck squamous cell carcinoma (HNSCC) cells can stimulate CAFs to release POSTN, an ECM protein, augmenting the inclination of neoplastic cells towards altered plasticity and metastasizing (Qin et al., 2016; González-González and Periostin, 2018).