In line, Wang et al. (2014a) showed malignancy and angiogenesis in nasopharyngeal carcinoma (NPC) in a VEGF/CXCL12-CXCR4 dependent manner, and the presence of EPCs was also confirmed with CD133+ cells in the tumor stroma. This evidence concerns the gene CXCL12 and nasopharyngeal carcinoma.