Overexpression of miR-128 suppresses HNSCC development by directly modulating its targets, Paip-interacting protein 2 (Paip2), BAG Cochaperone 2 (BAG-2), H3F3B, Bmi-1, and Bcl-2-associated X protein in proliferative and apoptotic processes, indicating that miR-128 acts as a tumor suppressor, in vitro and in vivo. This evidence concerns the gene BAG2 and neoplasm.