MAPK1 and cancer: Moreover, upregulation of miR-128 in NSCLC and human umbilical vein endothelial cells (HUVECs) resulted in decreased expression of VEGF-A, VEGF receptor (VEGFR)-2, and VEGFR-3, all of which are important factors in cancer lymphangiogenesis and tumorigenesis, as well as decreased phosphorylation of the phosphatidylinositol 3-kinase and extracellular signal-regulated kin (ERK) (25).