Type I diabetes is known for autoreactive T cell-mediated destruction of pancreatic islet cells; meanwhile, type II diabetes (T2D) develop low grade inflammation that scars tissue by exacerbating other T2D pathologies, such as insulin resistance and atherosclerotic plaque development and destabilization, and has recently been considered an autoimmune disease by some studies (25, 26, 106). The gene discussed is INS; the disease is type 2 diabetes mellitus.