F2 and Sepsis: Similarly, Xiang et al., 2021 proposed the pediatric sepsis-induced coagulation score (pSIC), which classifies immune-dysregulated pediatric sepsis patients based on prothrombin time, platelet count, and pediatric Sequential Organ Failure Assessment (SOFA) score derived from 4 items (respiratory SOFA, cardiovascular SOFA, hepatic SOFA, and renal SOFA).