In conclusion, this study systematically analyzed the expression, gene regulatory network, prognostic value, and target prediction of BRD2, BRD3, and BRD4 in patients with ACC, elucidated the association between BRD2, BRD3, BRD4 and ACC, and provided insights into the mechanism and treatment of ACC. This evidence concerns the gene BRD2 and adrenal cortex carcinoma.