Furthermore, the most frequently altered neighboring genes of BRD2, BRD3, and BRD4 in patients with ACC were CLDN23 (75.00%), PLEC (75.00%), MAL2 (75.00%), SYNE1 (75.00%), GPRIN2 (75.00%), ADAMTS13 (50.00%), NOTCH3 (55.56%), ANGPTL6 (44.44%), and C19ORF38 (44.44%) (Tables 1- 3). The gene discussed is SYNE1; the disease is adrenal cortex carcinoma.