Treatment of male infertility mentioned here include hormone human chorionic gonadotropin (hCG), selective estrogen receptor modulator clomiphene citrate (off-label drug for male infertility), and aromatase inhibitor Anastrazole (off-label drug for male infertility) to offset LH, FSH, and/or testosterone deficiencies. The gene discussed is PLOD1; the disease is male infertility.