Although the primary action of SGLT2i involves inhibition of SGLT2 expressed on proximal tubule cells, these drugs exhibit pleiotropic effects, which include reductions in body weight, blood pressure, intra-glomerular pressure, hyperuricemia, inflammation and oxidative stress, inhibition of the sympathetic nervous system, and improvements in erythropoiesis, cardiac energy metabolism and vascular function (91–93). This evidence concerns the gene SLC5A2 and hyperuricemia.