Previous research has established that lnc-MyD88 increases the expression of MyD88 through enhanced H3K27Ac in the promoter of the MyD88 gene, resulting in the activation of the NF-κB and The phosphatidylinositol 3-kinase/Protein kinase B(AKT) (PI3K/AKT) signaling pathways and then promoting the proliferation and transfer of HCC (23). The gene discussed is NFKB1; the disease is hepatocellular carcinoma.