Cultivated myoblasts from patients with mitochondrial disorders, such as chronic progressive external ophthalmoplegia (CPEO), mitochondrial encephalopathy lactic acidosis and stroke-like episodes (MELAS) and TMEM70 deficiency, had TEM section of mitochondria with fragmentation, shortening, and aberrant cristae (Sládková et al., 2015). This evidence concerns the gene TMEM70 and External ophthalmoplegia.