Meanwhile, inflammatory cells in BALF (Fig. 3C , P< 0.01), AHR (Fig. 3D, P < 0.01, at methacholine concentrations of 50.0 mg/ml), lung tissue damage (Fig. 3E a-c) and histological scores (HPS, Fig. 3E d , P< 0.01) all dramatically alleviated in the RSV + anti-IL-17A group as compared to the RSV group. This evidence concerns the gene IL17A and Hermansky-Pudlak syndrome.