TNF and lymphopenia: Gene ontology analysis [37] indicates that TNF induces the expression of over 50 cytokine response genes (GO:0,034,097), as well as transcripts encoding proteins related to cell–cell adhesion (including 15 cadherin-binding proteins (GO:0,045,296), and cysteine-type peptidases (GO:0,008,234), but suppresses 12 genes related to lymphopenia (HP:0,001,888).