Most BMPR2 variants were reported previously in patients with idiopathic pulmonary arterial hypertension (IPAH), while recent NGS and functional studies have revealed that p.S987F in BMPR2 caused isolated POI by perturbing BMP15/BMPR2/SMAD signaling and GCs proliferation [29]. Here, BMP15 is linked to idiopathic pulmonary arterial hypertension.