Previous studies have observed the activation of microglial cGAS–STING pathway in exogenous viral infections, traumatic brain injury, cerebral ischemic stroke, and Alzheimer's disease [50, 54–57], however, the activators of cGAS–STING pathway were come from exogenous virus or extracellular nucleic acids released by damaged or dead cells that phagocytized by microglia. Here, STING1 is linked to early-onset autosomal dominant Alzheimer disease.