IL-10 and transforming growth factor-β (TGF-β) in the TME can promote the transformation of γδT cells into tumor-promoting phenotypically distinct functional subgroups, such as γδT17 cells and γδTregs [72, 77]; in addition, inhibitory γδT cells tend to express CD39 and CD73 molecules [78–80], which can be signs of T-cell dysfunction [81–83]. This evidence concerns the gene TGFB1 and neoplasm.