The downregulation of β2M gene expression in tumor cells leads to the downregulation of MHC-I molecule expression on the cell surface and high expression of HLA-G, which can decrease the clonality of Vγ9Vδ2T cells and the secretion of IFN-γ because HLA-G can bind to inhibitory leukocyte immunoglobulin-like receptors (LIRs) or Ig-like transcripts (ILTs), such as ILT2 [102–105]. Here, HLA-G is linked to neoplasm.