Triglycerides independently predicted the PAI-1 expression in post treatment OCP group in our study which supports the prior research that PAI-1 contributes mechanically to a number of symptoms of the syndrome such as obesity, hypertension and insulin resistance [68] and that the crucial regulator of hepatic lipid metabolism is the PAI-1 [69]. This evidence concerns the gene SERPINE1 and obesity due to melanocortin 4 receptor deficiency.