As shown in Fig. 5B, combined rPK5 with rGal-3C exhibited weak inhibition on PLC/PRF/5 cell proliferation, but rPK5-RL-Gal-3C exhibited stronger inhibition, which demonstrated that the inhibitory action of rPK5-RL-Gal-3C on HCC cells is complicated synergy but not simple combination of PK5 and Gal-3C domains. This evidence concerns the gene HSPG2 and hepatocellular carcinoma.