In order to investigate the inhibitory effect of rPK5-RL-Gal-3C on tumor cell proliferation derived from synergy or combination of PK5 and Gal-3C domains, we further compared the inhibitory action between rPK5-RL-Gal-3C and combined rPK5 with rGal-3C (rPK5 + rGal-3C) at the same molar concentration (4 μmol/l). This evidence concerns the gene RELN and neoplasm.