To achieve the goal of this study, several publicly available databases, including COSMIC (https://cancer.sanger.ac.uk/cosmic), DisGeNET (https://www.disgenet.org), and HGNC (https://www.genenames.org) were used to extract some relevant information mostly related to SF3B1 and its variants in association with the investigated four types of cancer. The gene discussed is SF3B1; the disease is cancer.