CD4 and colitis: To further confirm the repressive role of Nsun2-deletion in T cell-mediated colitis development, we transferred wild-type or Nsun2cKO CD4+CD25−CD45RBhi naive T cells into Rag1−/− mice to induce CD45RBhi adoptive transfer mouse colitis, and found that mice receiving Nsun2cKO naive T cells didn’t show any disease phenotype up to 12 weeks after transfer.