The similar clinical phenotypes of Parkinsonism mutations in SJ1 (RQ mutation) and auxilin (complete LOF) as well as the similar cellular and histological phenotypes observed in SJ1-KIRQ and Aux-KO mice prompted us to examine a synergistic effect of the two genetic disruptions by generating Aux-KO/SJ1-KIRQ double mutant mice. Here, DNAJC6 is linked to Parkinsonism.