Etomoxir (CPT1a inhibitor) and GW9662 (PPAR inhibitor), which are both small molecule drugs can effectively reverse accumulation of TAMs in HCC tissues, which was found to dramatically decrease Arg1 and increases iNOS in RIPK3 KO TAMs, and ablation of FAO can switch RIPK3 KO TAM polarization from M2 to M1 [56]. This evidence concerns the gene PPARA and hepatocellular carcinoma.