M1-phenotype TAMs polarized from the peripheral blood mononuclear cells (PBMCs) are marked by relatively higher expression of IL-1β, TNF-α, IL-6, IL-12, HLA-DR(HLA-DRα), CCR7, Type I IFNγ, CXCL1–3, CXCL-5, CXCL8–10, CCL10, inducible nitric oxide synthase (iNOS or NOS2), MHC II, CD11c, CD80, CD86 and CD16/32 in HCC [44–55]. The gene discussed is NOS2; the disease is hepatocellular carcinoma.