VEGFA and neoplasm: In addition, along with the transition from the M1 to the M2 state, macrophages acquire features that can effectively promote tumor invasion, metastasis, and immunosuppression with upregulated expression of genes such as MMP14 (matrix metalloproteinase 14), VEGFA (vascular endothelial growth factor A), and MRC1/CD206 (mannose receptor) [13].