While both of these TFs reside in CAD associated loci, and thus may be directly linked to CAD risk8, we have decided to focus subsequent studies on FOXC1. The transcriptionally active A allele is more highly represented in its binding sites, FOXC1 mutations have been linked to PDGF signaling in the context of cerebral small vessel disease42, and this gene has also been linked to vascular risk factors including hypertension, systolic blood pressure, and waist hip ratio (GWAS catalog). This evidence concerns the gene FOXC1 and hypertensive disorder.