To further investigate the transcriptomic effects of PDGFD in the disease setting, we treated the lineage tracing atherosclerosis ApoE-/-mouse model with a murine derived inhibitory monoclonal antibody directed against Pdgfd (25E17, PD-ab) or with a control IgG (Ctl-ab) (Fig. 6a). The gene discussed is APOE; the disease is atherosclerosis.