ERN1 and intracerebral hemorrhage: Although CDNF was shown to regulate UPR initiated by transducers IRE1α, PERK and ATF6 in the pathological condition [29], we found that mRNA levels of UPR markers Grp78, spliced Xbp1, Atf4, and Chop were not significantly different between WT and Cdnf−/− mice after intracerebral hemorrhage (Fig. S1E).