To understand if necroptosis plays role in acute LCMV infection and disease, we infected WT, RIPK3-deficient (Ripk3−/−) or MLKL-deficient (Mlkl−/−) mice with a low dose LCMV Armstrong, an acute variant of the virus, and analyzed the immune response at day 8 post infection. The gene discussed is RIPK3; the disease is infection.