To correlate myeloid cell infiltration, LXR/cholesterol synthesis pathways and response to immunotherapy, we interrogated the scRNA-seq dataset of melanoma samples of ICB-responder and non-responder patients [44] and observed a statistically significant enrichment of ABCA1 and SCD transcripts in monocytes/macrophages of patients not responding to ICBs (Fig. 9H and Supplementary Table 3) (ABCA1 NR vs R = 1.52; P = 4.29 × 10-8; SCD NR vs R = 1.80; P = 2.93 × 10-5; Wilcoxon rank sum test). Here, SCD is linked to melanoma.