IL1B and rheumatoid arthritis: We performed a differential gene expression test and found a set of genes differentially expressed in KO-IR retinas, which are enriched for GO and KEGG terms such as response to lipopolysaccharide, regulation of inflammatory response, IL-1β production, and rheumatoid arthritis (Fig. 7B, C and Table S1), in agreement with a role of 181-Rik in inflammation.