In conclusion, this study revealed that radiation‐induced upregulation of ALKBH5 in HSC mediates TIRAP/NF‐κB pathway activation to promote HSC activation, while ALKBH5 regulates CCL5 secretion to promote monocyte recruitment and M2 polarisation, which further promotes ALKBH5 expression and activation of TIRAP/NF‐κB pathway in HSCs and HCC cells, which in turn aggravates RILF and reduces HCC radiosensitivity (Figure 7F). Here, TIRAP is linked to hepatocellular carcinoma.