High expression of ALKBH5/TIRAP axis was detected in tumour and paratumour tissues before or post radiotherapy from HCC patients who showed non‐response to radiotherapy but with concomitant RILI, compared to those patients responding to radiotherapy without RILI (Figure 7A–C), suggesting that these indicators may be used as potential markers for predicting radiotherapy response and complications of HCC. The gene discussed is TIRAP; the disease is hepatocellular carcinoma.