We were able to replicate findings from Ghanaians in independent cohorts including South African Batswana, African American, and European descent populations, which supports that these DMPs (TXNIP, CPT1A, ABCG1, EPSTI1) are potentially relevant in the pathogenesis of dyslipidaemia and are universal across different ancestral groups. The gene discussed is TXNIP; the disease is inherited lipid metabolism disorder.