Abbreviations: TDAs, tissue differentiation antigens; CGAs, cancer germline antigens; CR, complete response; PR, partial response by RECIST criteria; CEA, carcinoembryonic antigen; gp100, glycoprotein 100; HPV, human papillomavirus; MAGE-A, melanoma-associated antigen; MART-1, melanoma antigen recognized by T cells 1; NY-ESO-1, New York esophageal squamous cell carcinoma-1; MPNST, malign peripheral nerve sheath tumors; NSCLC, non–small cell lung cancer; CRS, cytokine release syndrome; n.s., not specified; KO-KI, knockout–knock-in; N.A., not available. Here, MLANA is linked to Down syndrome.