PRELP and heart disorder: PRELP protein is increased in the LV of late-stage but not early-stage ICM in pigs67 and in late-stage ICM in humans68 and has been suggested to be a biomarker for end-stage heart disease.59PRELP is thought to be increased in an intermediatory state along the fibroblast myofibroblast transition, and knockout of PRELP in fibroblasts leads to decreased activation of fibroblasts after TGB-β stimulation.14