PIK3C2A and acute myocardial infarction: Comparing ICM with NF patients in the EC-angiogenic population, we saw an increase in INSR and a decrease in PIK3C2A, a protein previously shown to be decreased in the plasma of patients after an acute myocardial infarction.38AFAP1L1, which is involved in actin stress fiber formation,39 was increased in both the EC-angiogenic and EC-general capillary populations (Figure 3).