MYH6, a gene well known to be associated with heart failure, was also identified.54 Several genes were identified that have been previously shown to play important roles in disease that may be druggable and have positive outcomes for heart disease, such as SMOC2,55SULF1,56SPARCL1,57NRK,58 and PRELP59 (Table S11). The gene discussed is SMOC2; the disease is heart failure.