Interesting DEGs in fibroblasts include: NTM, which has been identified as a novel biomarker for heart failure,18 and ANO1, which plays an important role in fibrosis in a rat model of myocardial infarction.19 In cardiomyocytes, PLCE1 has been shown to play a role in cardiac hypertrophy via its interaction with the scaffolding protein mAKAP6.20AZGP1 is a secreted protein that has been shown to have antifibrotic effects in the kidney and the heart21 and CALCOCO222 is a key protein in autophagy and its expression is associated with cardiac dysfunction in DCM. This evidence concerns the gene ANO1 and heart failure.