CELSR1 is an atypical cadherin that is associated with susceptibility to ischemic stroke in Japanese populations45 and congenital heart disease associated pulmonary arterial hypertension.46IREB2 was increased in pericytes in ICM compared with NF and in ICM compared with DCM and is involved in ferroptosis, a pathway that has been implicated in myocardial infarction and heart disease.47TMLHE is the first enzyme in the carnitine/acylcarnitine biosynthesis pathway and was decreased in endothelial III cells in ICM compared with NF and in ICM compared with DCM. This evidence concerns the gene CELSR1 and congenital heart disease.