PCNA and benign prostatic hyperplasia: Another study showed that the 70% ethanol extract of Euodiae Fructus could inhibit the growth of benign prostatic hyperplasia-1 (BPH-1) epithelial cells by inhibiting proteins and antigens including 5α-reductase, proliferating cell nuclear antigen (PCNA), phosphor-ERK1/2, and cyclin D1 and by inhibiting cell viability dependently through the activation of caspase-3 and caspase-8 [97].