TLR7 and skin disorder: In other studies, rutaecarpine ameliorated sepsis-induced peritoneal resident macrophages apoptosis and inflammation responses through inhibition of endoplasmic reticulum stress-mediated caspase-12 and NF-κB pathways [120], improved imiquimod-induced psoriasis-like dermatitis through effects on pDC- and Th17-associated cytokines via modulation of NF-κB and toll-like receptor 7 (TLR7) signaling [220], and ameliorated dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) via inhibiting KEAP1-NRF2 interaction to activate NRF2 [122].