BDNF and Alzheimer disease: Cai et al. demonstrated that the water extract of Euodiae Fructus significantly ameliorated learning and memory deficits in Morris water maze tests, and in 3xTg AD mice, it could also decrease Aβ deposits and increase NeuN-positive cells by upregulating the expressions of Brain neurotrophic derived factor (BDNF) and tyrosine kinase B (TrkB) [105].